Professionals never cease their interests in
studying bi-specific antibody. How much of you know about bispecific
antibodies? Bispecific antibodies, BsAbs in short, are bioengineered antibodies
that contain two different binding sites within a single molecule, which can
specifically bind two different types of antigen.
The most widely used application of bi-specific
antibody is in cancer immunotherapy, which creates a therapeutic treatment
approach for diseases with specific medical needs.
Compared with traditional antibodies, bispecific
antibodies have many advantages. The two arms can bring an antigen-expressing
cell in close proximity to a killing cell and thus destroy the tumor cell; the
two binding sites can significantly increase affinity or internalization rates
of particular antigens on a cell's surface by binding to two different epitopes
on an antigen; they usually have a higher cytotoxic potential to bind to
antigens with low expression level. Binding tumor cells using a bi-specific
antibody-drug conjugate (ADC) also holds great promise for the future
development of therapeutics for a variety of diseases.
With the development of antibody engineering,
many types of bispecific antibodies have been designed to enable short
half-life, immunogenicity and side-effects caused by cytokine liberation. They
include tri-functional antibodies, chemically linked Fabs, and various types of
bivalent and trivalent single-chain variable fragments (scFvs), fusion proteins
mimicking the variable domains of two antibodies. The furthest developed of
these newer formats are the bi-specific T-cell engagers (BiTEs) and mAb2's,
antibodies engineered to contain an Fcab antigen-binding fragment instead of
the Fc constant region.
As a leader in the field of antibody engineerin, Creative Biolabs
has developed CeativeAbTM antibodies in order to increase the
efficacy of current therapeutic antibodies.
Various Types of bispecific antibodies Creative
Biolabs offers:
u Tri-functional antibodies and chemically linked
Fabs
u Bivalent,and Bispecific scFvs (tandem scFv,
diabodies)
u Bi-specific T-cell engagers (BiTEs)
u scFv-Fab Fusion Proteins
Based on various antibody formats such as IgGs,
Fabs and scFvs, Creative Discovery PlatformTM of Creative Biolabs provides a
series of bispecific antibodies to satisfy various needs from its customers. It
provides construction, including expression and purification as well as
recombinant antibody production at scales, ranging from hundreds of micrograms
to grams level.
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